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Liver fibrogenesis: a new role for the renin-angiotensin system. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. 2004 Aug 15; 78(3):324-32. 2010 Oct; 52(4):1420-30. 2020 May 05; 56(5). Curr Opin Gastroenterol. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Proc Natl Acad Sci U S A. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Hepatology. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. WebBrenners new job suits his eclecticism. JCI Insight. Hum Gene Ther. 1980 Apr 03; 302(14):765-9. 2015 Nov-Dec; 49 Suppl 1:S25-7. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. Nat Commun. 2006 May; 130(6):1564-72. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15184-15193. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. 2007 Dec; 47(6):834-43. 2005 Sep; 289(3):G530-8. 2004 Oct; 127(4):1260-2. Fra, Fra away: the complex role of activator protein 1 in liver injury. 2014 Apr 29; 63(16):1626-33. Am J Physiol Gastrointest Liver Physiol. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Yang L, Magness ST, Bataller R, Rippe RA. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. 2018 07; 15(7):397-411. Curr Opin Gastroenterol. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Note that an individual publication can be assigned to more than one field. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. Hepatology. Integr Biol (Camb). Mol Metab. 2000 Sep 29; 275(39):30597-604. 2000 Apr 21; 275(16):11814-23. 1999 Aug; 21(2):238-45. DNA Cell Biol. 2013 Jun; 45(6):450-9. J Lab Clin Med. 2004 Jan; 2(1):9-13. 2003 Oct; 125(4):1009. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. J Biol Chem. 2019 03; 156(4):1156-1172.e6. Clin Immunol. This graph shows the total number of publications by year. Am J Physiol. Hepatology. Blood. Gastroenterol Res Pract. 2001 Apr 10; 103(14):1920-7. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Clin Gastroenterol Hepatol. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. Transplantation. Weight Loss Decreases Magnetic Resonance Elastography Estimated Liver Stiffness in Nonalcoholic Fatty Liver Disease. Hepatology. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. Semin Liver Dis. Exp Neurol. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. Gastroenterology. Cell Mol Gastroenterol Hepatol. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. 2015 May; 31(3):184-91. 2007 Nov; 13(11):1324-32. J Clin Immunol. J Immunol. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Hepatology. Mol Cell Biol. J Theor Biol. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. FASEB J. 2015 Feb; 4(1):34-47. Hepatology. 2020; 11:370. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. 2005 Sep 16; 335(1):87-96. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. 2022; 17(9):e0274219. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Hepatology. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. Contemp Intern Med. 1988 Apr 25; 263(12):5841-5. 2007 Apr; 132(4):1434-46. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. N Engl J Med. J Hepatol. 2016 07; 111(7):986-94. Nat Med. 1999 Nov; 20(11):2095-100. 1994 Dec; 124(6):755-60. Exercise training attenuates age-associated diastolic dysfunction in rats. Hepatology. J Hepatol. Hepatology. J Bone Miner Res. 2013 Sep; 183(3):820-30. Hepatic porphyrias. Am J Physiol Gastrointest Liver Physiol. 1994 Sep; 17(3):410-2. Liver Int. Cell Metab. Antioxid Redox Signal. 1998 Sep; 13(S1):S39-S50. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. 2005 May; 41(5):1085-95. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Expression of human immunodeficiency virus-1 in human colonic cells. 2009 Jan 16; 378(3):348-53. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. Int J Mol Med. 2021; 16(12):e0260721. Activation of activating protein 1 during hepatic acute phase response. Am J Physiol Gastrointest Liver Physiol. 2002 Dec; 36(6):1498-508. 2018 12; 68(6):2059-2061. Hellerbrand C, Jobin C, Licato LL, Sartor RB. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. 2020 12; 72(6):2182-2196. 1989 Sep; 30(9):1220-4. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Am J Clin Nutr. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. 2019 02 04; 216(2):267-278. Alteration of interferon-a/ receptors in chronic hepatitis B patients. Hepatology. 2013 Jul; 145(1):16-31. Iimuro Y, Bradford BU, Gao W, Kadiiska M, Mason RP, Stefanovic B. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. Luedde T, Rodriguez ME, Tacke F, Xiong Y. Am J Physiol. Hepatology. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! J Clin Invest. Transient induction of c-jun during hepatic regeneration. 2006 Jul 27; 82(2):241-50. 2007 Jun; 22 Suppl 1:S73-8. 2022 08; 42(3):233-249. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. J Biol Chem. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. A simplified method for the preparation of transcriptionally active liver nuclear extracts. 2004 Feb; 126(2):529-40. J Biol Chem. 2007 Apr-Jun; 6(2):83-8. 1996 Sep; 50(3):656-61. Cell Metab. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. 2014 Oct 28; 83(18):1653-60. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. medRxiv. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. The fecal microbiome of ALS patients. In 2012, Jacobs and his wife, Joan, jumpstarted the Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. Mol Cell Biol. 2020 05; 72(5):946-959. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. J Clin Exp Hepatol. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. 1999 Apr 15; 162(8):4447-54. 2003 Apr; 38(4):468-75. Awareness, treatment, and control of vascular risk factors among stroke survivors. 1997 Jan 17; 272(3):1753-60. 2003 Jan 10; 278(2):927-33. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. 1989 May; 8(4):279-85. David has 2 jobs listed on their profile. Mol Endocrinol. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. 1990 Apr; 7(2):105-15. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. J Immunol. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. 2014 Oct; 27(5):413-25. 1998 Feb 15; 101(4):802-11. 1992 Jun; 50(6):1203-10. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. 1994 Dec 09; 269(49):30789-97. Transforming growth factor B and hepatic fibrosis: cause or effect? Stroke. Mol Genet Genomic Med. 2022 09; 609(7925):101-108. 2012; 7(4):e34218. Role of Gut Microbiota in Liver Disease. Front Biosci. 2001 Aug; 21(3):437-51. J Biol Chem. Medicina (Kaunas). 2012 Sep; 143(3):765-776.e3. Cell Death Differ. 2008 Dec; 173(6):1617-27. 2020 11 03; 32(5):878-888.e6. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. 1997 May; 25(5):1128-35. Proc Natl Acad Sci U S A. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. 2020 Feb; 21(2):89-98. 1993 Jan; 17(1):164-6. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. What is the potential role of antifibrotic agents for the treatment of liver disease? Cancer Res. Transplantation. Clin Gastroenterol Hepatol. J Biol Chem. 2010 Feb 25; 3:39-47. Hepatitis C and alcohol: fundamental and translational research directions. 2012 Nov; 143(5):1330-1340.e1. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. 2009 Sep; 50(3):929-38. Gastroenterology. Transplantation. 1998 08; 275(2):G269-78. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. 1986 Mar; 83(6):1762-6. Biochem Soc Symp. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. 2012 Dec; 56(6):2316-27. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. Am J Physiol Gastrointest Liver Physiol. Exp Biol Med (Maywood). PNAS Nexus. 2017 01; 65(1):78-88. Alcohol. FASEB J. 1998 Jan 01; 160(1):410-8. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. 2004 Aug 01; 173(3):1561-70. AIDS. 2013 Feb 01; 12(3):381-2. CCR1 and CCR5 promote hepatic fibrosis in mice. 2012 May 22; 109(21):E1369-76. Identification of small molecule activators of cryptochrome. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. 2009 May; 40(5):1721-8. 1988 Sep-Oct; 8(5):1040-5. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology. Clin Res Hepatol Gastroenterol. A logical approach to the patient with jaundice. J Clin Gastroenterol. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. Gastroenterology. 1989 May; 9(5):2224-7. Curr Opin Gastroenterol. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. WebDavid Brenner. Nature. 2003 Nov; 112(9):1383-94. Front Physiol. Circulation. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. Akt activation protects rat liver from ischemia/reperfusion injury. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. 2012 Nov; 67(11):1357-64. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Hepatology. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Hepatology. Gastroenterology. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. He replaces David A. Brenner as vice chancellor for Health Sciences, who stepped down on July 1, 2022. I. TNF-induced liver injury. Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. 2009 Jan; 49(1):6-8. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. PLoS One. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Gastroenterology. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. 1999 Mar; 15(2):103-7. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. Gastroenterology. Int J Mol Sci. The role of Smad3 in mediating mouse hepatic stellate cell activation. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. 2007 Dec; 133(6):2019-28. Antioxid Redox Signal. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 2000 Jul; 33(1):49-58. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. 2011 Apr; 25(2):305-17. 1999 09; 277(3):G671-7. 2013 Feb; 57(2):577-89. 2004 May 28; 279(22):23822-9. 1994 Sep; 14 (9):5950-60. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Cell Host Microbe. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Yale J Biol Med. Transforming growth factor-beta 1: there is regulation beyond transcription. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. 2011 Jun; 31(3):521-32. NF-kappaB activation in Kupffer cells after partial hepatectomy. Liver Int. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. 2006 Apr; 43(4):872-8. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. 2014 Aug; 124(8):3566-78. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA. Involvement of death receptor-related signaling pathways. 1993 Dec; 92(6):2916-21. 2009 Oct; 137(4):1467-1477.e5. A role for lipid peroxidation? Hepatology. 2013 Apr; 144(4):661-3. 2008 Mar; 23 Suppl 1:S98-103. 1998 Nov; 18(11):6353-64. 2008 Jul; 255(7):993-1000. Neurology. Identification of Novel Fibrosis Modifiers by InVivo siRNA Silencing. Am J Physiol. Gastroenterology. J Gastroenterol Hepatol. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. Proc Natl Acad Sci U S A. 2021 08 01; 321(2):H435-H445. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Clin Gastroenterol Hepatol. A method for in vitro DNase I footprinting analysis on supercoiled templates. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. 2005 Jun; 42(6):850-9. 2010 Sep; 139(3):836-45, 845.e1. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Proc Am Thorac Soc. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. 2017 12 12; 8(1):2137. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. He did not respond to inewsource s interview request. 2007 May; 132(6):2272-5. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Researchers can. Int J Biochem Cell Biol. Am J Pathol. Nat Commun. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Expression of collagen genes in the liver. 1999 Jun; 29(6):1680-9. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Mol Biol Med. 2006 Jul; 37(7):1691-6. 1990 Jan; 85(1):248-55. 2009 Nov; 58(11):1517-27. What's new in liver fibrosis? 2013; 8(2):e56116. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. 1999 Mar; 31(2):173-9. Gastroenterology. J Gastroenterol Hepatol. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Am J Physiol Gastrointest Liver Physiol. Hepatology. 2000 Jan 15; 28(2):641-7. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. La Jolla groups issue letter on city parks master plan. 1999 Aug; 31(4):305-19. Proc Natl Acad Sci U S A. Infect Immun. 1995; (33):212-4. Aliment Pharmacol Ther. 2019 01; 17(2):218-230. J Gastroenterol Hepatol. 2009; 44 Suppl 19:1-7. Biotechniques. Gastroenterology. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. Hepatology.

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